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Título:
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Notch signaling in astrocytes mediates their morphological response to an inflammatory challenge
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Autores:
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Acaz Fonseca, Estefanía ;
Ortiz Rodriguez, Ana ;
Azcoitia Elías, Iñigo ;
García-Segura, Luis Miguel ;
Arévalo, María Ángeles
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Tipo de documento:
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texto impreso
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Editorial:
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Springer, 2019-04-03
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Dimensiones:
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application/pdf
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Nota general:
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cc_by
info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Biología: Biología celular
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Tipo = Artículo
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Resumen:
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In the nervous system, Notch pathway has a prominent role in the control of neuronal morphology and in the determination of the astrocyte fate. However, the role of Notch in morphological astrocyte plasticity is unknown. Here, we have explored the role of Notch activity on the morphological reactivity of primary astrocytes in response to LPS, an inflammatory stimulus. We found that LPS induces reactive astrocyte morphology by the inhibition of Notch signaling via NF?B activation and Jagged upregulation. In contrast, IGF-1, an anti-inflammatory molecule, inhibits LPS-induced reactive astrocyte morphological phenotype by enhancing Notch signaling through the inhibition of NF?B and the activation of MAPK. Therefore, Notch signaling pathway emerges as a mediator of the regulation of astrocyte morphology by inflammatory and anti-inflammatory stimuli.
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En línea:
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https://eprints.ucm.es/57284/1/Acaz-Fonseca-DBC-Notch-signaling-in-astrocytes.pdf
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