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Román, Domingo ; Pizarro, I. ; Rivera, L. ; Cámara Rica, Carmen ; Palacios Corvillo, M.Antonia ; Gómez Gómez, M.Milagros ; Solar, Carlos | SAGE | 2010Among non-cancer effects of arsenic, cardiovascular diseases have been well documented; however, few are known about the arsenic fate in cardiovascular tissues. We studied the analytic bioinorganic arsenic behaviour in cardiovascular tissues fro[...]texto impreso
Pizarro, I. ; Roman Silva, D.A. ; Gómez Gómez, M.Milagros ; Cámara Rica, Carmen ; Palacios Corvillo, M.Antonia | Chilean Chemical Society | 2013The intracellular As-protein binding in cytosol and methanol–water extract of the auricle and saphene tissues of As impacted people was evaluated by bidimensional size exclusion FPLC-UV-ICP-MS. The fractionation of cytosol using Superdex, Phenom[...]texto impreso
SEC-ICP-MS and ESI-MS as tools to study the interaction between cisplatin and cytosolic biomolecules
Esteban Fernández, Diego ; Cañas, Benito ; Pizarro, I. ; Palacios Corvillo, M.Antonia ; Gómez Gómez, M.Milagros | RSC | 2007Most of cisplatin’s citotoxic properties are due to the interaction of the drug with DNA. However, other biological molecules present in the cell cytosol, such as MT (metallothionein) and GSH (glutathione), are potential targets for cisplatin an[...]
