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Manterola, Andrea ; Bernal Chico, Ana ; Cipriani, Raffaela ; Canedo Antelo, Manuel ; Moreno García, Álvaro ; Martín Fontecha, Mar ; Pérez Cerdá, Fernando ; Sánchez Gómez, María Victoria ; Ortega Gutiérrez, Silvia ; Brown, J. Mark ; Hsu, Ku-Lung ; Cravatt, Benjamin ; Matute, Carlos ; Mato, Susana | Elsevier | 2018-08Multiple sclerosis (MS) is a chronic demyelinating disease of unknown etiology in which tissue pathology suggests both immune-dependent attacks to oligodendroglia and primary oligodendrocyte demise. The endocannabinoid system has been crucially [...]texto impreso
Gil Ordóñez, Ana ; Martín Fontecha, Mar ; Ortega Guitérrez, Silvia ; López Rodríguez, María Luz | Elsevier | 2018-11Monoacylglycerol lipase (MAGL) has been characterized as the main enzyme responsible for the inactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2-AG). Besides this role, MAGL has progressively acquired a growing imp[...]texto impreso
Marín Ramos, Nagore Isasbel ; Balabasquer Peña, Moisés ; Ortega Nogales, Francisco Jesús ; Torrecillas, Iván R. ; Gil Ordóñez, Ana ; Marcos Ramiro, Beatriz ; Aguilar Garrido, Pedro ; Cushman, Ian ; Romero, Antonio ; Medrano, Francisco J. ; Gajate Fraile, Consuelo ; Mollinedo García, Faustino ; Philips, Mark R. ; Campillo, Mercedes ; Gallardo Delgado, Miguel ; Martín Fontecha, Mar ; López Rodríguez, María Luz ; Ortega Gutiérrez, Silvia | American Chemical Society (ACS) | 2019-06-10Blockade of Ras activity by inhibiting its post-translational methylation catalyzed by isoprenylcysteine carboxylmethyltransferase (ICMT) has been suggested as a promising antitumor strategy. However, the paucity of inhibitors has precluded the [...]
