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Título:
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The growth threshold conjecture: a theoretical framework for understanding T-cell tolerance
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Autores:
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Arias, Clemente F. ;
Herrero, Miguel A. ;
Cuesta, José A. ;
Acosta Salmerón, Francisco Javier ;
Fernández Arias, Cristina
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Tipo de documento:
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texto impreso
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Editorial:
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Royal Society (London), 2015-07-01
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Dimensiones:
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application/pdf
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Nota general:
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cc_by
info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Medicina: Inmunología
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Materia = Ciencias Biomédicas: Biología: Biología molecular
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Materia = Ciencias Biomédicas: Biología: Biomatemáticas
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Tipo = Artículo
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Resumen:
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Adaptive immune responses depend on the capacity of T cells to target specific antigens. As similar antigens can be expressed by pathogens and host cells, the question naturally arises of how can T cells discriminate friends from foes. In this work, we suggest that T cells tolerate cells whose proliferation rates remain below a permitted threshold. Our proposal relies on well-established facts about T-cell dynamics during acute infections: T-cell populations are elastic (they expand and contract) and they display inertia (contraction is delayed relative to antigen removal). By modelling inertia and elasticity, we show that tolerance to slow-growing populations can emerge as a population-scale feature of T cells. This result suggests a theoretical framework to understand immune tolerance that goes beyond the self versus non-self dichotomy. It also accounts for currently unexplained observations, such as the paradoxical tolerance to slow-growing pathogens or the presence of self-reactive T cells in the organism.
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En línea:
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https://eprints.ucm.es/55039/1/Arias%2C%20C.%20F.%20et%20al.%202015.%20The%20growth%20threshold%20conjeture.....pdf
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