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Título:
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Human thymic stromal lymphopoietin preferentially stimulates myeloid cells
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Autores:
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Reche, Pedro A ;
Soumelis, Vassili ;
Gorman, D M ;
Clifford, T ;
Liu, MR ;
Travis, M ;
Zurawski, Sandra M. ;
Johnston, J ;
Liu, Yong-Jun ;
Spits, H ;
Waal-Malefyt, Rene de ;
Kastelein, Robert A. ;
Bazan, Fernando
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Tipo de documento:
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texto impreso
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Editorial:
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The American Association of Immunologists, 2001
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Dimensiones:
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application/pdf
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Nota general:
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info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Medicina: Inmunología
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Materia = Ciencias Biomédicas: Biología: Biotecnología
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Materia = Ciencias Biomédicas: Biología: Biología molecular
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Tipo = Artículo
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Resumen:
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The sequence of a novel hemopoietic cytokine was discovered in a computational screen of genomic databases, and its homology to mouse thymic stromal lymphopoietin (TSLP) suggests that it is the human orthologue. Human TSLP is proposed to signal through a heterodimeric receptor complex that consists of a new member of the hemopoietin family termed human TSLP receptor and the IL-7R alpha-chain. Cells transfected with both receptor subunits proliferated in response to purified, recombinant human TSLP, with induced phosphorylation of Stat3 and Stat5. Human TSLPR and IL-7Ralpha are principally coexpressed on monocytes and dendritic cell populations and to a much lesser extent on various lymphoid cells. In accord, we find that human TSLP functions mainly on myeloid cells; it induces the release of T cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells, as evidenced by the strong induction of the costimulatory molecules CD40 and CD80 and the enhanced capacity to elicit proliferation of naive T cells.
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En línea:
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https://eprints.ucm.es/id/eprint/9345/1/12.Reche_etal_JI_2001.pdf
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