|
Título:
|
Lempel-Ziv complexity in schizophrenia: A MEG study
|
|
Autores:
|
Fernández, A. ;
López-Ibor, M.I. ;
Turrero, Agustín ;
Santos, J. M. ;
Morón, M.D. ;
Hornero, R. ;
Gómez, C. ;
Méndez, M.A. ;
Ortiz, T. ;
López-Ibor, J.J.
|
|
Tipo de documento:
|
texto impreso
|
|
Editorial:
|
Elsevier, 2011-11
|
|
Dimensiones:
|
application/pdf
|
|
Nota general:
|
info:eu-repo/semantics/openAccess
|
|
Idiomas:
|
|
|
Palabras clave:
|
Estado = Publicado
,
Tipo = Artículo
|
|
Resumen:
|
Objective: The neurodevelopmental-neurodegenerative debate is a basic issue in the field of the neuropathological basis of schizophrenia (SCH). Neurophysiological techniques have been scarcely involved in such debate, but nonlinear analysis methods may contribute to it. Methods: Fifteen patients (age range 23-42. years) matching DSM IV-TR criteria for SCH, and 15 sex- and age-matched control subjects (age range 23-42. years) underwent a resting-state magnetoencephalographic evaluation and Lempel-Ziv complexity (LZC) scores were calculated. Results: Regression analyses indicated that LZC values were strongly dependent on age. Complexity scores increased as a function of age in controls, while SCH patients exhibited a progressive reduction of LZC values. A logistic model including LZC scores, age and the interaction of both variables allowed the classification of patients and controls with high sensitivity and specificity. Conclusions: Results demonstrated that SCH patients failed to follow the " normal" process of complexity increase as a function of age. In addition, SCH patients exhibited a significant reduction of complexity scores as a function of age, thus paralleling the pattern observed in neurodegenerative diseases. Significance: Our results support the notion of a progressive defect in SCH, which does not contradict the existence of a basic neurodevelopmental alteration.
|
|
En línea:
|
https://eprints.ucm.es/id/eprint/30852/1/Turrero02abierto.pdf
|
