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Título:
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Antitumoral effect of maintained neutrophilia induced by rhG-CSF in a murine model of pancreatic cancer
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Autores:
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Bru Espino, Antonio ;
Bosch, R. ;
Céspedes, M. V. ;
Carmona-Güedes, S. ;
Pascual, E. ;
Brú, I. ;
Souto, J. C.
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Tipo de documento:
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texto impreso
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Editorial:
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Springer Nature, 2019-02-27
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Dimensiones:
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application/pdf
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Nota general:
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cc_by
info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias: Matemáticas
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Materia = Ciencias Biomédicas: Medicina: Inmunología
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Materia = Ciencias Biomédicas: Medicina: Oncología
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Tipo = Artículo
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Resumen:
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Although the protumoral functions of polymorphonuclear neutrophils are well known, some now-forgotten studies report antitumoral roles for these cells. The present work examines the antitumoral effect of maintained neutrophilia induced via the injection of recombinant human granulocyte colony stimulating factor (rhG-CSF, 100??g/kg/day) in a Panc-1 subcutaneous xenograft murine model of pancreatic cancer. This treatment was compared with gemcitabine administration (120?mg/kg every two days) and a saline control (n?=?6–7 mice per group). Compared to the controls, both the rhG-CSF- and gemcitabine-treated mice showed significantly suppressed tumor growth by day 4 (p?0.001 and p?=?0.013 respectively). From a mean starting volume of 106.9?±?3.1?mm3 for all treatment groups, the final mean tumor volumes reached were 282.0?±?30.7?mm3 for the rhG-CSF-treated mice, 202.6?±?18.1?mm3 for the gemcitabine-treated mice and 519.4?±?62.9?mm3 for the control mice (p?0.004 and p?0.01, respectively, vs. control). The rhG-CSF-treated tumors showed higher percentage necrosis than those treated with gemcitabine (37.4?±?4.6 vs. 7.5?±?3.0; p?0.001). This is the first report of a clear anti-tumoral effect of rhG-CSF when used in monotherapy against pancreatic cancer. Since rhG-CSF administration is known to be associated with very few adverse events, it may offer an attractive alternative in the clinical treatment of pancreatic cancer.
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En línea:
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https://eprints.ucm.es/51719/1/Bru25.pdf
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