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Blockage of the neonatal leptin surge affects the gene expression of growth factors, glial proteins and neuropeptides involved in the control of metabolismand reproduction in peri-pubertal male and femalerats

Mela Rivas, Virginia ; Díaz, Francisca ; López Rodríguez, Ana Belén ; Vázquez, María Jesús ; Gertler, Arieh ; Argente, Jesús ; Tena-Sempere, Manuel ; Viveros, María Paz ; Chowen, Julie A. | Oxford University Press | 2015-07

Leptin is important in the development of neuroendocrine circuits involved in metabolic control. As both leptin and metabolism influence pubertal development, we hypothesized that early changes in leptin signaling could also modulate hypothalami[...]

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