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Título:
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SatR is a repressor of fluoroquinolone efflux pump SatAB
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Autores:
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Escudero, José Antonio ;
San Millán, Álvaro ;
Montero Serra, Natalia ;
Gutiérrez, Belén ;
Martínez Ovejero, Cristina ;
Carrilero Aguado, Laura ;
González Zorn, Bruno
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Tipo de documento:
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texto impreso
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Editorial:
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American Society for Microbiology, 2013-07
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Dimensiones:
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application/pdf
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Nota general:
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info:eu-repo/semantics/restrictedAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Veterinaria
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Tipo = Artículo
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Resumen:
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Streptococcus suis is an emerging zoonotic agent responsible for high-mortality outbreaks among the human population in China. In this species, the ABC transporter SatAB mediates fluoroquinolone resistance when overexpressed. Here, we describe and characterize satR, an open reading frame (ORF) encoding a MarR superfamily regulator that acts as a repressor of satAB. satR is cotranscribed with satAB, and its interruption entails the overexpression of the pump, leading to a clinically relevant increase in resistance to fluoroquinolones.
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En línea:
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https://eprints.ucm.es/id/eprint/39657/1/547.pdf
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