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Título:
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Eph/ephrins-mediated thymocyte–thymic epithelial cellinteractions control numerous processes of thymus biology
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Autores:
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García Ceca Hernández, Javier ;
Alfaro Sánchez, David ;
Montero Herradón, Sara ;
Tobajas, Esther ;
Muñoz, Juan José ;
Zapata González, Agustín
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Tipo de documento:
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texto impreso
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Editorial:
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Frontiers Media, 2015-06-26
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Dimensiones:
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application/pdf
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Nota general:
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cc_by
info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Biología
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Materia = Ciencias Biomédicas: Biología: Biología celular
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Tipo = Artículo
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Resumen:
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Numerous studies emphasize the relevance of thymocyte–thymic epithelial cell (TECs) interactions for the functional maturation of intrathymic T lymphocytes. The tyrosine kinase receptors, Ephs (erythropoietin-producing hepatocyte kinases) and their ligands, ephrins (Eph receptor interaction proteins), are molecules known to be involved in the regulation of numerous biological systems in which cell-to-cell interactions are particularly relevant. In the last years, we and other authors have demonstrated the importance of these molecules in the thymic functions and the T-cell development. In the present report, we review data on the effects of Ephs and ephrins in the functional maturation of both thymic epithelial microenvironment and thymocyte maturation as well as on their role in the lymphoid progenitor recruitment into the thymus.
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En línea:
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https://eprints.ucm.es/41965/1/Alfaro%202015%20Eph%20ephrins-mediated%20thymocyte-thymic.pdf
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