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Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction

Gómez, A. ; Gómez Sánchez, José ; López Torres, Mónica ; Naudi, Alba ; Mota Martorrell, N. ; Pamplona, R. ; Barja de Quiroga, Gustavo | Springer | 2015-06

It has been described that dietary cysteine reverses many of the beneficial changes induced by methionine restriction in aging rodents. In this investigation male Wistar rats were subjected to diets low in methionine, supplemented with cysteine,[...]

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Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice

Martínez Cisuelo, V. ; Gómez, J. ; García Junceda, I. ; Naudi, Alba ; Cabré, R. ; Mota Martorell, N. ; López Torres, Mónica ; González Sánchez, Mónica ; Pamplona, R. ; Barja de Quiroga, Gustavo | Elsevier | 2016-10

Rapamycin consistently increases longevity in mice although the mechanism of action of this drug is unknown. In the present investigation we studied the effect of rapamycin on mitochondrial oxidative stress at the same dose that is known to incr[...]

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