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Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice

Martínez Cisuelo, V. ; Gómez, J. ; García Junceda, I. ; Naudi, Alba ; Cabré, R. ; Mota Martorell, N. ; López Torres, Mónica ; González Sánchez, Mónica ; Pamplona, R. ; Barja de Quiroga, Gustavo | Elsevier | 2016-10

Rapamycin consistently increases longevity in mice although the mechanism of action of this drug is unknown. In the present investigation we studied the effect of rapamycin on mitochondrial oxidative stress at the same dose that is known to incr[...]

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