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Título:
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Neuroprotective Effects of Low-Dose Statins in the Retinal Ultrastructure of Hypercholesterolemic Rabbits
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Autores:
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Fernández Navarro, Judith ;
Aldea Mansilla, Pilar ;
Hoz Montañana, María Rosa de ;
Salazar Corral, Juan José ;
Ramírez Sebastián, Ana Isabel ;
Rojas López, Blanca ;
Gallego Collado, Beatriz Isabel ;
Triviño Casado, Alberto ;
Tejerina Sánchez, Teresa ;
Ramirez Sebastian, Jose Manuel
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Tipo de documento:
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texto impreso
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Editorial:
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Public Library Science, 2016-05-04
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Dimensiones:
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application/pdf
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Nota general:
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cc_by
info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Medicina: Oftalmología
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Materia = Ciencias Biomédicas: Óptica y optometría: Anatomía ocular
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Materia = Ciencias Biomédicas: Farmacia: Medicamentos
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Tipo = Artículo
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Resumen:
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To evaluate the pleiotropic effects to statins, we analyze the qualitative and quantitative retinal changes in hypercholesterolemic rabbits after a low-dosage statin treatment. For this purpose, New Zealand rabbits were split into three groups: control (G0; n = 10), fed a standard diet; hypercholesterolemic (G1; n = 8), fed a 0.5% cholesterol-enriched diet for 8 months; and statins (G2; n = 8), fed a 0.5% cholesterol-enriched diet for 8 months, together with the administration of statin (pravastatin or fluvastatin sodium) at a dose of 2 mg / kg / day each diet. The retinas were analyzed by transmission electron microscopy and immunohistochemistry (glial fibrillary acidic protein). The retinal thickness of nuclear and plexiform layers were quantified in semi-thin sections. The results revealed that the low-statin-treated rabbits in comparison with the hypercholesterolemic group showed: i) a more preserved structure in all retinal layers; ii) a significant reduction in retinal thickness; iii) a decrease in cell death in the nuclear-and ganglion-cell layers; iv) a reduction of hydropic degeneration in the plexiform and nerve-fiber layers; v) a preservation of astrocytes and of the retinal area occupied by them; and vi) a better-preserved retinal vascular structure. Our findings indicate that low doses of statins can prevent retinal degeneration, acting on retinal macroglia, neurons and retinal vessels, despite that hypercholesterolemia remained unchanged. Thus, the pleiotropic effects of the statins may help safeguard the retinal ultrastructure.
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En línea:
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https://eprints.ucm.es/45188/1/Salazar_Neuroprotective-Plos-2016.PDF
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