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Título:
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Lysine-Grafted MCM-41 Silica as An Antibacterial Biomaterial
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Autores:
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Villegas, Fernanda ;
Garcia-Uriostegui, Lorena ;
Rodríguez, Ofelia ;
Izquierdo-Barba, Isabel ;
Salinas Sánchez, Antonio J. ;
Toriz, Guillermo ;
Vallet Regí, María ;
Delgado, Ezequiel
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Tipo de documento:
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texto impreso
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Editorial:
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MDPI, 2017
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Dimensiones:
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application/pdf
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Nota general:
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cc_by
info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias: Química: Ingeniería química
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Materia = Ciencias: Química: Química inorgánica
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Tipo = Artículo
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Resumen:
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Abstract: A facile strategy for zwitterionization of bioceramics based on direct incorporation of L-lysine amino acid via the ?-amino group onto mesoporous MCM-41 materials is proposed. FTIR studies of lysine-grafted MCM-41 (MCM-LYS) showed simultaneously bands at 3080 and 1540 cm?1 and bands at 1625 and 1415 cm?1 corresponding to -NH3+/COO? pairs, demonstrating the incorporation of the amino acid on the material surface keeping its zwitterionic character. Both elemental and thermogravimetric analyses showed that the amount of grafted lysine was 8 wt % based on the bioceramic total weight. Moreover, MCM-LYS material exhibited a reduction of adhesion of S. aureus and E. coli bacteria in 33 and 50%, respectively at physiological pH, as compared with pristine MCM-41. Biofilm studies onto surfaces showed that lysine functionalization elicited a reduction of the area covered by S. aureus biofilm from 42% to only 5% (88%). This research shows a simple and effective approach to chemically modify bioceramics using single amino acids that provide zwitterionic functionality, useful to develop new biomaterials able to resist bacterial adhesion.
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En línea:
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https://eprints.ucm.es/id/eprint/44871/1/bioengineering-224181.pdf
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