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Título:
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The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in Arabidopsis
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Autores:
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Wijnker, Erik ;
Harashima, Hirofumi ;
Müller, Katja ;
Parra Núñez, Pablo ;
Bastiaan de Snoo, C. ;
Van de Belt, José ;
Dissmeyer, Nico ;
Bayer, Martin ;
Pradillo, Mónica ;
Schnittger, Arp
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Tipo de documento:
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texto impreso
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Editorial:
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National Academy of Sciences, 2019-06
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Dimensiones:
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application/pdf
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Nota general:
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cc_by_nc_nd
info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Biología: Botánica
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Materia = Ciencias Biomédicas: Biología: Genética
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Tipo = Artículo
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Resumen:
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Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in Arabidopsis. Arabidopsis plants with reduced CDKA;1 activity experienced a decrease of class I COs, especially lowering recombination rates in centromere-proximal regions. Interestingly, this reduction of type I CO did not affect CO assurance, a mechanism by which each chromosome receives at least one CO, resulting in all chromosomes exhibiting similar genetic lengths in weak loss-of-function cdka;1 mutants. Conversely, an increase of CDKA;1 activity resulted in elevated recombination frequencies. Thus, modulation of CDKA;1 kinase activity affects the number and placement of COs along the chromosome axis in a dose-dependent manner.
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En línea:
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https://eprints.ucm.es/id/eprint/58122/1/Wijnker%2C%20E.%20et%20al.%202019.%20The%20Cdk1%20Cdk2%20homolog....pdf
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