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Autilio, Chiara ; Shankar-Aguilera, Shivani ; Minucci, Angelo ; Touqui, Lhoussaine ; De Luca, Daniele | American Physiological Society | 2019-02-21Hypothermia can modify surfactant composition and function. Secretory phospholipase A2 (sPLA2) hydrolyses surfactant phospholipids and is important in the pathobiology of several critical respiratory disorders. We hypothesize that sPLA2 activity[...]texto impreso
De Luca, Daniele ; Shankar-Aguilera, Shivani ; Autilio, Chiara ; Raschetti, Roberto ; Vedovelli, Luca ; Fitting, Catherine ; Payré, Christine ; Jeammet, Louise ; Pérez Gil, Jesús ; Cogo, Paola E. ; Carnielli, Virgilio P. ; Lambeau, Gérard ; Touqui, Lhoussaine | American Physiological Society | 2020-06-25Secreted phospholipase A2 hydrolyzes surfactant phospholipids and is crucial for the inflammatory cascade; preterm neonates are treated with exogenous surfactant, but the interaction between surfactant and phospholipase is unknown. We hypothesiz[...]
