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Resumen:
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Neospora caninum, the causal agent of neosporosis, is an apicomplexan obligate intracellular parasite closely phylogenetically related to Toxoplasma gondii. Bovine neosporosis causes severe economic losses in dairy and beef industries due to the abortion and still birth of calves. Currently, there are no effective vaccines or treatments against infection by N. caninum, and control options are based on diagnosis and management practices. Neospora caninum infection underlies a complex immunological regulation that may lead to protection or contribute to the pathogenesis of abortion. Interactions of the parasite with cells of the host immune system during early infection (innate immune response), which represent the first line of defense against infections, should be critical in determining the character of the subsequent response. Macrophages play a key role in initiating early-immune responses against infections and establishing a link with the adaptive immune response. Despite the fact that these cells are essential for combating N. caninum infection, a limited number of studies have been conducted to investigate N. caninum-macrophages interaction, and most of them used murine and human cells. However, human and mouse are not natural hosts for N. caninum an dit has been demonstrated that parasite virulence can be host-specific...
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