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2-Deoxy-D-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: Involvement of IGF-1R-regulated Akt/mTOR, MEK/ERK and LKB-1/ AMPK signaling pathways

Estañ, María Cristina ; Calviño, Eva ; Blas, Elena de ; Boyano Adánez, María del Carmen ; Mena, María Luz ; Gómez Gómez, M.Milagros ; Rial, Eduardo ; Aller, Patricio | Elsevier | 2012

While the anti-tumor efficacy of 2-deoxy-D-glucose (2-DG) is normally low in monotherapy, it may represent a valuable radio- and chemo-sensitizing agent. We here demonstrate that 2–10 mM 2-DG cooperates with arsenic trioxide (ATO) and other anti[...]

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