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Título:
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Clinical and Molecular-Genetic Insights into the Role of Oxidative Stress in Diabetic Retinopathy: Antioxidant Strategies and Future Avenues
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Autores:
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Sanz González, Silvia María ;
García Medina, José Javier ;
Zanón Moreno, Vicente ;
López Gálvez, María Isabel ;
Galarreta Mira, David ;
Duarte, Lilianne ;
Valero Velló, Mar ;
Ramírez Sebastián, Ana Isabel ;
Arévalo, J. Fernando ;
Pinazo Durán, Mª Dolores
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Tipo de documento:
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texto impreso
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Editorial:
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MDPI, 2020-11-09
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Dimensiones:
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application/pdf
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Nota general:
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cc_by
info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Medicina: Dietética y nutrición
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Materia = Ciencias Biomédicas: Medicina: Oftalmología
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Materia = Ciencias Biomédicas: Óptica y optometría: Anatomía ocular
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Tipo = Artículo
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Resumen:
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Reactive oxygen species (ROS) overproduction and ROS-signaling pathways activation attack the eyes. We evaluated the oxidative stress (OS) and the effects of a daily, core nutritional supplement regimen containing antioxidants and omega 3 fatty acids (A/?3) in type 2 diabetics (T2DM). A case-control study was carried out in 480 participants [287 T2DM patients with (+)/without (?) diabetic retinopathy (DR) and 193 healthy controls (CG)], randomly assigned to a daily pill of A/?3. Periodic evaluation through 38 months allowed to outline patient characteristics, DR features, and classic/OS blood parameters. Statistics were performed by the SPSS 24.0 program. Diabetics displayed significantly higher circulating pro-oxidants (p = 0.001) and lower antioxidants (p = 0.0001) than the controls. Significantly higher plasma malondialdehyde/thiobarbituric acid reactive substances (MDA/TBARS; p = 0.006) and lower plasma total antioxidant capacity (TAC; p = 0.042) and vitamin C (0.020) was found in T2DM + DR versus T2DM-DR. The differential expression profile of solute carrier family 23 member 2 (SLC23A2) gene was seen in diabetics versus the CG (p = 0.001), and in T2DM + DR versus T2DM ? DR (p
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En línea:
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https://eprints.ucm.es/id/eprint/63110/1/Ramirez%20Sebastian%20Ana_2020_antioxidants-09-01101-v2.pdf
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