| Título: | Impaired Mesopic Visual Acuity in Eyes with Early Age-Related Macular Degeneration |
| Autores: | Puell Marín, María Cinta ; Barrio de Santos, Ana Rosa ; Palomo Álvarez, Catalina ; Gomez-Sanz, Fernando J ; Clement-Corral, Amaya ; Pérez Carrasco, María Jesús |
| Tipo de documento: | texto impreso |
| Editorial: | The Association for Research in Vision and Ophthalmology, Inc., 2012 |
| Dimensiones: | application/pdf |
| Nota general: |
cc_by_nc_nd info:eu-repo/semantics/openAccess |
| Idiomas: | |
| Palabras clave: | Estado = Publicado , Materia = Ciencias Biomédicas: Medicina: Oftalmología , Materia = Ciencias Biomédicas: Óptica y optometría: Optometría , Tipo = Artículo |
| Resumen: |
Purpose.: To determine photopic and mesopic distance high-contrast visual acuity (HC-VA) and low-contrast visual acuity (LC-VA) in eyes with early age-related macular degeneration (AMD). Methods.: Measurements were made in 22 subjects with early AMD and 28 healthy control subjects. Inclusion criteria included a photopic HC-VA of 20/25 or better. Distance VA was measured using HC (96%) and LC (10%) Bailey-Lovie logMAR letter charts under photopic (85 cd/m2) and mesopic (0.1–0.2 cd/m2) luminance conditions. Results.: Mean mesopic distance HC-VA and LC-VA were significantly worse (0.1 logMAR and 0.28 logMAR, respectively) in the early AMD group than in the control group. Under mesopic conditions, the mean difference between LC-VA and HC-VA was significantly greater in the early AMD (0.45 logMAR) than the control group (0.27 logMAR). Mean differences between mesopic versus photopic HC-VA and mesopic versus photopic LC-VA were significantly greater in the early AMD than the control group (0.13 and 0.32 logMAR of difference between the means, respectively). Sensitivity and specificity were significantly greater for mesopic LC-VA than for mesopic HC-VA (Receiver Operating Characteristics, area under the curve [AUC], 0.94 ± 0.030 and 0.76 ± 0.067, respectively). AUC values for photopic HC-VA and LC-VA were below 0.70. Conclusions.: Visual acuity testing under low luminance conditions emerged as an optimal quantitative measure of retinal function in early AMD. |
| En línea: | https://eprints.ucm.es/39858/1/Invest%20Opht%20Vis%20Sci%20%281%29.pdf |
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