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Immobilized enzyme reactors based on nucleoside phosphorylases and 2?-deoxyribosyltransferase for the in-flow synthesis of pharmaceutically relevant nucleoside analogues

Rinaldi, Francesca ; Fernández-Lucas, Jesús ; Fuente, Diego de la ; Zheng, Changping ; Bavaro, Teodora ; Peters, Benjamin ; Massolini, Gabriella ; Annunziata, Francesca ; Conti, Paola ; Mata, Isabel de la ; Terreni, Marco ; Calleri, Enrica | Elsevier | 2020-03-26

In this work, a mono- and a bi-enzymatic analytical immobilized enzyme reactors (IMERs) were developed as prototypes for biosynthetic purposes and their performances in the in-flow synthesis of nucleoside analogues of pharmaceutical interest wer[...]

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