Título:
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TLR4 modulation: molecular recognition studies and drug design by molecular modelling
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Autores:
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Billod, Jean-Marc
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Tipo de documento:
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texto impreso
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Editorial:
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Universidad Complutense de Madrid, 2018-05-04
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Dimensiones:
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application/pdf
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Nota general:
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info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = No publicado
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Materia = Ciencias Biomédicas: Farmacia: Farmacología
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Materia = Ciencias Biomédicas: Farmacia: Química farmaceútica
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Tipo = Tesis
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Resumen:
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The heterodimeric complex, formed by Toll-Like Receptor 4 (TLR4) and its accessory protein Myeloid Differentiation factor 2 (MD-2) is responsible of activating the innate immune system when sensing the presence of particular pathogen-associated molecular patterns (PAMPs) from bacteria. The outer membrane of Gram-negative bacteria is primarily populated by lipopolysaccharides (LPS) which are essential for their growth and survival. These LPSs are specifically recognized by the TLR4/MD-2 complex as follows: an LPS binds to MD-2 inside a deep molecular hydrophobic pocket causing molecular rearrangements of the receptorial complex resulting in the dimerization of another TLR4/MD-2 unit. TLR4 ectodomains dimerization event brings together the TLR4 intercellular domains initiating the activation of innate immune system signaling pathways. Interestingly, this activation is not only modulated by naturally occurring LPSs from many different Gram-negative bacteria but also by non-naturally occurring glycolipids and other non-LPS like molecules...
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En línea:
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https://eprints.ucm.es/id/eprint/51156/1/T40865.pdf
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