| Título: | Impacts of age and sex on retinal layer thicknesses measured by spectral domain optical coherence tomography with Spectralis |
| Autores: | Nieves Moreno, María ; Martínez de la Casa, Jose Maria ; Morales Fernández, Laura ; Sánchez Jean, Rubén ; Sáenz Francés, Federico ; García Feijoo, Julián |
| Tipo de documento: | texto impreso |
| Editorial: | Public Library Science, 2018-03-09 |
| Dimensiones: | application/pdf |
| Nota general: |
cc_by info:eu-repo/semantics/openAccess |
| Idiomas: | |
| Palabras clave: | Estado = Publicado , Materia = Ciencias Biomédicas: Medicina: Diagnóstico por imagen y medicina nuclear , Materia = Ciencias Biomédicas: Medicina: Oftalmología , Tipo = Artículo |
| Resumen: |
Objective: To examine differences in individual retinal layer thicknesses measured by spectral domain optical coherence tomography (SD-OCT) (Spectralis®) produced with age and according to sex. Design: Cross-sectional, observational study. Methods: The study was conducted in 297 eyes of 297 healthy subjects aged 18 to 87 years. In one randomly selected eye of each participant the volume and mean thicknesses of the different macular layers were measured by SD-OCT using the instrument's macular segmentation software. Main outcome measures: Volume and mean thickness of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigmentary epithelium (RPE) and photoreceptor layer (PR). Results: Retinal thickness was reduced by 0.24 ?m for every one year of age. Age adjusted linear regression analysis revealed mean GCL, IPL, ONL and PR thickness reductions and a mean OPL thickness increase with age. Women had significantly lower mean GCL, IPL, INL, ONL and PR thicknesses and volumes and a significantly greater mRNFL volume than men. Conclusion: The thickness of most retinal layers varies both with age and according to sex. Longitudinal studies are needed to determine the rate of layer thinning produced with age. |
| En línea: | https://eprints.ucm.es/47055/1/Martinez%20de%20la%20Casa_impacts%20retinal%20layer-plus%20one-2018.pdf |
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