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Título:
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Fitting DNA sequences through log-linear modelling with linear constraints
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Autores:
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Martín Apaolaza, Níriam ;
Pardo Llorente, Leandro
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Tipo de documento:
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texto impreso
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Editorial:
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Taylor & Francis, 2011
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Dimensiones:
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application/pdf
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Nota general:
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info:eu-repo/semantics/restrictedAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias: Matemáticas: Estadística matemática
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Tipo = Artículo
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Resumen:
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For some discrete state series, such as DNA sequences, it can often be postulated that its probabilistic behaviour is given by a Markov chain. For making the decision on whether or not an uncharacterized piece of DNA is part of the coding region of a gene, under the Markovian assumption, there are two statistical tools that are essential to be considered: the hypothesis testing of the order in a Markov chain and the estimators of transition probabilities. In order to improve the traditional statistical procedures for both of them when stationarity assumption can be considered, a new version for understanding the homogeneity hypothesis is proposed so that log-linear modelling is applied for conditional independence jointly with homogeneity restrictions on the expected means of transition counts in the sequence. In addition we can consider a variety of test-statistics and estimators by using phi-divergence measures. As special case of them the well-known likelihood ratio test-statistics and maximum-likelihood estimators are obtained.
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En línea:
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https://eprints.ucm.es/id/eprint/17348/1/PardoLeandro03.pdf
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