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Esteban Fernández, Diego ; Moreno Gordaliza, Estefanía ; Cañas, Benito ; Palacios Corvillo, M.Antonia ; Gómez Gómez, M.Milagros | RSC | 2010Pt-containing drugs are nowadays essential components in cancer chemotherapy. However, drug resistance and side effects limit the efficiency of the treatments. In order to improve the response to Pt-based drugs, different administration strategi[...]texto impreso
SEC-ICP-MS and ESI-MS as tools to study the interaction between cisplatin and cytosolic biomolecules
Esteban Fernández, Diego ; Cañas, Benito ; Pizarro, I. ; Palacios Corvillo, M.Antonia ; Gómez Gómez, M.Milagros | RSC | 2007Most of cisplatin’s citotoxic properties are due to the interaction of the drug with DNA. However, other biological molecules present in the cell cytosol, such as MT (metallothionein) and GSH (glutathione), are potential targets for cisplatin an[...]texto impreso
Esteban Fernández, Diego ; Gómez Gómez, M.Milagros ; Cañas, Benito ; Verdaguer, J.M. ; Ramírez, R. ; Palacios Corvillo, M.Antonia | Elsevier | 2007Chemical compounds containing platinum have been employed since 1978 as drugs to beat certain type of tumours. Nevertheless, besides of their exceptional antitumoral properties, these drugs also have important deleterious side effects, such as, [...]
