| Título: | Strontium-releasing mesoporous bioactive glasses with anti-adhesive zwitterionic surface as advanced biomaterials for bone tissue regeneration |
| Autores: | Pontremolli, Carlotta ; Izquierdo Barba, Isabel ; Montalbano, Giorgia ; Vallet Regí, María ; Vitale-Brovarone, Chiara ; Fiorilli, Sonia |
| Tipo de documento: | texto impreso |
| Editorial: | Elsevier, 2019-12-14 |
| Dimensiones: | application/pdf |
| Nota general: | info:eu-repo/semantics/embargoedAccess |
| Idiomas: | |
| Palabras clave: | Estado = Publicado , Materia = Ciencias: Química: Materiales , Materia = Ciencias Biomédicas: Farmacia: Química inorgánica , Tipo = Artículo |
| Resumen: |
Hypothesis The treatment of bone fractures still represents a challenging clinical issue when complications due to impaired bone remodelling (i.e. osteoporosis) or infections occur. These clinical needs still require a radical improvement of the existing therapeutic approach through the design of advanced biomaterials combining the ability to promote bone regeneration with anti-adhesive properties able to minimise unspecific biomolecules adsorption and bacterial adhesion. Strontium-containing mesoporous bioactive glasses (Sr-MBG), which are able to exert a pro-osteogenic effect by releasing Sr2+ ions, have been successfully functionalised to provide mixed-charge (-NH3 ?/-COO?) surface groups with anti-adhesive abilities. Experiments Sr-MBG have been post-synthesis modified by co-grafting hydrolysable short chain silanes containing amino (aminopropylsilanetriol) and carboxylate (carboxyethylsilanetriol) moieties to achieve a zwitterionic zero-charge surface. The final system was then characterised in terms of textural-structural properties, bioactivity, cytotoxicity, pro-osteogenic and anti-adhesive capabilities. Findings After zwitterionization the in vitro bioactivity was maintained, as well as the ability to release Sr2+ ions which are capable of inducing a mineralization process. Irrespective of their size, Sr-MBG particles did not exhibit any cytotoxicity in pre-osteoblastic MC3T3-E1 up to the concentration of 75 µg/mL. Finally, the zwitterionic Sr-MBGs showed a significant reduction of serum protein adhesion with respect to the pristine ones. These results open promising future expectations in the design of nanosystems which combine pro-osteogenic and anti-adhesive properties. |
| En línea: | https://eprints.ucm.es/id/eprint/58181/1/Version%20Aceptada%20del%20JICS-main.pdf |
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