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Título:
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Collagenase nanocapsules: An approach to ?brosis treatment
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Autores:
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Villegas, Maria Rocio ;
Baeza, Alejandro ;
Usategui Corral, Alicia ;
Ortiz-Romero, Pablo L. ;
Pablos, J. L. ;
Vallet Regí, María
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Tipo de documento:
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texto impreso
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Editorial:
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Elsevier, 2018-05-03
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Dimensiones:
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application/pdf
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Nota general:
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info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = En prensa
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Materia = Ciencias: Química: Materiales
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Materia = Ciencias Biomédicas: Farmacia: Química inorgánica
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Tipo = Artículo
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Resumen:
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Fibrosis is a common lesion in different pathologic diseases and de?ned by the excessive accumulation ofcollagen. Different approaches have been used to treat different conditions characterized by ?brosis. TheFDA and EMA approved the use of collagenase to treat palmar ?bromatosis (Dupuytren’s contracture).The EMA approved additionally its use in severe Peyronie’s disease, but it has been used off label in otherconditions [1,2]. The approved treatment includes up to three (in palmar ?bromatosis) or up to eight (inpenile ?bromatosis) injections followed by ?nger extension or penile modeling procedures, typicallycausing severe pain. Frequent single injections are adequate to treat palmar ?bromatosis [3]. The needto repeatedly inject doses of this enzyme can be due to the labile nature of collagenase, which exhibitsa complete activity loss after a short period of time. This study presents a novel strategy to manage thisenzyme based on the synthesis of polymeric nanocapsules that contain collagenase encapsulated withintheir matrix. These nanocapsules have been engineered for achieving a gradual release of the encapsu-lated enzyme for a longer time, which can be up to ten days. The ef?cacy of these nanocapsules has beentested in a murine model of local dermal ?brosis, and the results demonstrate a reduction in ?brosisgreater than that with the injection of free enzyme; this type of treatment showed a signi?cant improve-ment compared to conventional therapy of free collagenase.
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En línea:
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https://eprints.ucm.es/id/eprint/47562/1/1-s2.0-S1742706118302769-main.pdf
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