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Título:
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TRPV4 Stimulation Induced Melatonin Secretion by Increasing Arylalkymine N-acetyltransferase (AANAT) Protein Level
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Autores:
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Alkozi, Hanan Awad ;
Pérez de Lara, María Jesús ;
Sánchez Naves, Juan ;
Pintor, Jesús
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Tipo de documento:
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texto impreso
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Editorial:
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MDPI, 2017-04
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Dimensiones:
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application/pdf
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Nota general:
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cc_by
info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Medicina: Bioquímica
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Materia = Ciencias Biomédicas: Medicina: Oftalmología
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Tipo = Artículo
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Resumen:
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Melatonin is a molecule which has gained a great deal of interest in many areas of science; its synthesis was classically known to be in the pineal gland. However, many organs synthesize melatonin, such as several ocular structures. Melatonin is known to participate in many functions apart from its main action regulating the circadian rhythm. It is synthesized from serotonin in two steps, with a rate-limiting step carried out by arylalkymine N-acetyltransferase (AANAT). In this report, the role of TRPV4 channel present in human ciliary body epithelial cells in AANAT production was studied. Several experiments were undertaken to verify the adequate time to reach the maximal effect by using the TRPV4 agonist GSK1016790A, together with a dose–response study. An increase of 2.4 folds in AANAT was seen after 18 h of incubation with 10 nM of GSK1016790A (p
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En línea:
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https://eprints.ucm.es/42824/1/Pintor_TRPV4-IntJMolSci-2017.pdf
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