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Título:
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Complexity analysis of spontaneous brain activity in alzheimer disease and mild cognitive impairment: An MEG study
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Autores:
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Fernández, Alberto ;
Hornero, Roberto ;
Gómez, Carlos ;
Turrero, Agustín ;
Gil Gregorio, Pedro ;
Matías Santos, Juan ;
Ortiz, Tomás
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Tipo de documento:
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texto impreso
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Editorial:
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Wolters Kluwer Health, 2010-04
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Dimensiones:
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application/pdf
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Nota general:
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info:eu-repo/semantics/restrictedAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias: Matemáticas: Estadística aplicada
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Materia = Ciencias Biomédicas: Biología
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Tipo = Artículo
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Resumen:
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Nonlinear analyses have shown that Alzheimer disease (AD) patients' brain activity is characterized by a reduced complexity and connectivity. The aim of this study is to define complexity patterns of mild cognitive impairment (MCI) patients. Whole-head magnetoencephalography recordings were obtained from 18 diagnosed AD patients, 18 MCI patients, and 18 healthy controls during resting conditions. Lempel-Ziv complexity (LZC) values were calculated. MCI patients exhibited intermediary LZC scores between AD patients and controls. A combination of age and posterior LZC scores allowed ADs-MCIs discrimination with 94.4% sensitivity and specificity, whereas no LZC score allowed MCIs---controls discrimination. AD patients and controls showed a parallel tendency to diminished LZC scores as a function of age, but MCI patients did not exhibit such “normal” tendency. Accordingly, anterior LZC scores allowed MCIs-controls discrimination for subjects below 75 years. MCIs exhibited a qualitatively distinct relationship between aging and complexity reduction, with scores higher than controls in older individuals. This fact might be considered a new example of compensatory mechanism in MCI before fully established dementia.
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En línea:
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https://eprints.ucm.es/id/eprint/30887/1/Turrero06oficial.pdf
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