| Título: | Characterisation of the porcine eyeball as an in-vitro model for dry eye |
| Autores: | Meduni, Francesco ; Davies, Leon N. ; Madrid Costa, David ; Fratini, Antonio ; Wolffsohn, James S. |
| Tipo de documento: | texto impreso |
| Editorial: | Elsevier BV, 2018-02 |
| Dimensiones: | application/pdf |
| Nota general: | info:eu-repo/semantics/restrictedAccess |
| Idiomas: | |
| Palabras clave: | Estado = Publicado , Materia = Ciencias Biomédicas: Medicina: Oftalmología , Materia = Ciencias Biomédicas: Óptica y optometría: Optometría , Materia = Ciencias Biomédicas: Óptica y optometría: Óptica fisiológica , Tipo = Artículo |
| Resumen: |
Purpose: To characterise the anatomical parameters of the porcine eye for potentially using it as a laboratory model of dry eye. Methods: Anterior chamber depth and angle, corneal curvature, shortest and longest diameter, endothelial cell density, and pachymetry were measured in sixty freshly enucleated porcine eyeballs. Results: Corneal steepest meridian was 7.85 ± 0.32 mm, corneal flattest meridian was 8.28 ± 0.32 mm, shortest corneal diameter was 12.69 ± 0.58 mm, longest corneal diameter was 14.88 ± 0.66 mm and central corneal ultrasonic pachymetry was 1009 ± 1 ?m. Anterior chamber angle was 28.83 ± 4.16°, anterior chamber depth was 1.77 ± 0.27 mm, and central corneal thickness measured using OCT was 1248 ± 144 ?m. Corneal endothelial cell density was 3250 ± 172 cells/mm2. Conclusions: Combining different clinical techniques produced a pool of reproducible data on the porcine eye anatomy, which can be used by researchers to assess the viability of using the porcine eye as an in-vitro/ex-vivo model for dry eye. Due to the similar morphology with the human eye, porcine eyeballs may represent a useful and cost effective model to individually study important key factors in the development of dry eye, such as environmental and mechanical stresses. |
| En línea: | https://eprints.ucm.es/id/eprint/47264/1/Madrid%2C%20David%20Characterisation%20of%20the%20porcine%20eyeball%20as%20an%20in-vitro%20model%20for%20dry%20eye.pdf |
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