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Título:
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Osmoprotectants in Hybrid Liposome/HPMC Systems as Potential Glaucoma Treatment
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Autores:
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Gómez Ballesteros, Miguel ;
López Cano, José Javier ;
Bravo Osuna, Irene ;
Herrero Vanrell, Rocío ;
Molina Martínez, Irene Teresa
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Tipo de documento:
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texto impreso
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Editorial:
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MDPI, 2019
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Dimensiones:
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application/pdf
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Nota general:
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cc_by
info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Medicina: Oftalmología
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Materia = Ciencias Biomédicas: Farmacia: Farmacología
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Tipo = Artículo
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Resumen:
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The combination of acetazolamide-loaded nano-liposomes and Hydroxypropyl methylcellulose (HPMC) with similar components to the preocular tear film in an osmoprotectant media (trehalose and erythritol) is proposed as a novel strategy to increase the ocular bioavailability of poorly soluble drugs. Ophthalmic formulations based on acetazolamide-loaded liposomes, dispersed in the osmoprotectant solution (ACZ-LP) or in combination with HPMC (ACZ-LP-P) were characterized and in vivo evaluated. The pH and tonicity of both formulations resulted in physiological ranges. The inclusion of HPMC produced an increment in viscosity (from 0.9 to 4.7 mPa·s. 64.9 ± 2.6% of acetazolamide initially included in the formulation was retained in vesicles. In both formulations, a similar onset time (1 h) and effective time periods were observed (7 h) after a single instillation (25 µL) in normotensive rabbits’ eyes. The AUC0–8h of the ACZ-LP-P was 1.5-fold higher than of ACZ-LP (p
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En línea:
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https://eprints.ucm.es/id/eprint/62950/1/polymers-11-00929.pdf
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