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Public Library Science |
Documentos disponibles de esta editorial (37)
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Travis, Emma R ; Gaze, William H ; Pontiroli, Alessandra ; Sweeney, Francis P ; Porter, David ; Mason, Sam ; Keeling, Matthew J C ; Jones, Rebecca M ; Sawyer, Jason ; Aranaz Martín, Alicia ; Castellanos Rizaldos, Elena ; Cork, Jennifer ; Delahay, Richard J ; Wilson, Gavin J ; Hewinson, R Glyn ; Courtenay, Orin ; Wellington, Elizabeth M H | Public Library Science | 2011Advances in the diagnosis of Mycobacterium bovis infection in wildlife hosts may benefit the development of sustainable approaches to the management of bovine tuberculosis in cattle. In the present study, three laboratories from two different co[...]texto impreso
Cifuentes Canorea, Pilar ; Ruiz Medrano, Jorge ; Gutierrez Bonet, Rosa ; Peña García, Pablo ; Sáenz Francés, Federico ; García Feijoo, Julián ; Martínez de la Casa, Jose Maria | Public Library Science | 2018-04-19Objective: To analyse the morphological features and diagnostic ability of eight macular retinal layers using a new segmentation software Heidelberg's Spectralis Optical Coherence Tomography (SD-OCT) in healthy, ocular hypertensive and primary o[...]texto impreso
Wörner, Ch. ; Olguín, A. ; Ruiz-García, Jose Luis ; Garzón Jiménez, Nuria | Public Library Science | 2011-05-13A review of the current data on the cell density of normal adult human endothelial cells was carried out in order to establish some common parameters appearing in the different considered populations. From the analysis of cell growth patterns, i[...]texto impreso
Aguado Urda, Mónica ; Gibello Prieto, Alicia ; Blanco Gutiérrez, M Mar ; López Campos, Guillermo H ; Cutuli Simón, M Teresa ; Fernández Garayzábal, José F | Public Library Science | 2012The present work describes the molecular characterization of five circular plasmids found in the human clinical strain Lactococcus garvieae 21881. The plasmids were designated pGL1-pGL5, with molecular sizes of 4,536 bp, 4,572 bp, 12,948 bp, 14,[...]texto impreso
Pérez de Diego, Ana Cristina ; Athmaram, Thimmasandra N ; Stewart, Meredith ; Rodríguez Sánchez, Belén ; Sánchez-Vizcaíno, José Manuel ; Noad, Robert ; Roy, Polly | Public Library Science | 2011BACKGROUND Bluetongue virus (BTV) is an economically important, arthropod borne, emerging pathogen in Europe, causing disease mainly in sheep and cattle. Routine vaccination for bluetongue would require the ability to distinguish between vaccin[...]texto impreso
De la Fuente, Jose ; Díez Delgado, Iratxe ; Contreras, Marinela ; Vicente, Joaquín ; Cabezas Cruz, Alejandro ; Tobes, Raquel ; Manrique, Marina ; López, Vladimir ; Romero Martínez, Beatriz ; Bezos Garrido, Javier ; Domínguez Rodríguez, Lucas ; Sevilla, Iker A ; Garrido, Joseba M ; Juste, Ramón ; Madico, Guillermo ; Jones-López, Edward ; Gortazar, Christian | Public Library Science | 2015-11Mycobacteria of the Mycobacterium tuberculosis complex (MTBC) greatly affect humans and animals worldwide. The life cycle of mycobacteria is complex and the mechanisms resulting in pathogen infection and survival in host cells are not fully unde[...]texto impreso
Gené-Sampedro, Andrés ; Alonso Pla, Francisco ; Sánchez Ramos, Celia ; Useche, Sergio A. | Public Library Science | 2021-02-05Objective The objective of this study was to assess and compare drivers’ and non-drivers’ outcomes in the Adult Developmental Eye Movement test (ADEM), a visual-verbal test that measures the time needed to read series of numbers in both a vertic[...]texto impreso
Giménez Lirola, Luis G ; Mur, Lina ; Rivera Arroyo, Belén ; Mogler, Mark ; Sun, Yaxuan ; Lizano, Sergio ; Goodell, Christa ; Harris, D L Hank ; Rowland, Raymond R R ; Gallardo, Carmina ; Sánchez-Vizcaíno, José Manuel ; Zimmerman, Jeff | Public Library Science | 2016In the absence of effective vaccine(s), control of African swine fever caused by African swine fever virus (ASFV) must be based on early, efficient, cost-effective detection and strict control and elimination strategies. For this purpose, we dev[...]texto impreso
Navarro González, Nora ; Mentaberre, Gregorio ; Porrero, Concepción M ; Serrano, Emmanuel ; Mateos García, Ana ; López Martín, José M ; Lavín, Santiago ; Domínguez Rodríguez, Lucas | Public Library Science | 2012Salmonella is distributed worldwide and is a pathogen of economic and public health importance. As a multi-host pathogen with a long environmental persistence, it is a suitable model for the study of wildlife-livestock interactions. In this work[...]texto impreso
Guta, Sintayehu ; Casal, Jordi ; Napp, Sebastian ; Saez, Jose Luis ; Garcia Saenz, Ariadna ; Perez de Val, Bernat ; Romero Martínez, Beatriz ; Alvarez, Julio ; Allepuz, Alberto | Public Library Science | 2014We analyzed the most likely cause of 687 bovine tuberculosis (bTB) breakdowns detected in Spain between 2009 and 2011 (i.e., 22% of the total number of breakdowns detected during this period). Seven possible causes were considered: i) residual i[...]texto impreso
González Pérez, Mariano ; Susi García, Rosario ; Barrio de Santos, Ana Rosa ; Antona Peñalba, Beatriz | Public Library Science | 2018-08-28Purpose: To quantify the levels of performance (symptom severity) of the computer-vision symptom scale (CVSS17), confirm its bifactorial structure as detected in an exploratory factor analysis, and validate its factors as subscales. Methods: By [...]texto impreso
Zamora Morales, Leydis ; Fernández Garayzábal, José F ; Sánchez Porro, Cristina ; Palacios, Mari Angel ; Moore, Edward R B ; Domínguez Rodríguez, Lucas ; Ventosa, Antonio ; Vela Alonso, Ana I | Public Library Science | 2013Five strains (1126-1H-08(T), 51B-09, 986-08, 1084B-08 and 424-08) were isolated from diseased rainbow trout. Cells were Gram-negative rods, 0.7 µm wide and 3 µm long, non-endospore-forming, catalase and oxidase positive. Colonies were circular, [...]texto impreso
Aguado Urda, Mónica ; Gibello Prieto, Alicia ; Blanco, M del Mar ; Fernández Garayzábal, José F ; López Alonso, Victoria ; López Campos, Guillermo H | Public Library Science | 2013Lactococcus garvieae is an important fish and an opportunistic human pathogen. The genomic sequences of several L. garvieae strains have been recently published, opening the possibility of global studies on the biology of this pathogen. In this [...]texto impreso
García Antón, María Teresa ; Salazar Corral, Juan José ; Hoz Montañana, Rosa de ; Rojas López, Blanca ; Ramírez Sebastián, Ana Isabel ; Triviño Casado, Alberto ; Aroca Aguilar, José Daniel ; García Feijoo, Julián ; Escribano, Julio ; Ramirez Sebastian, Jose Manuel | Public Library Science | 2017-04-27Mutations in the CYP1B1 gene are currently the main known genetic cause of primary congenital glaucoma (PCG), a leading cause of blindness in children. Here, we analyze for the first time the CYP1B1 genotype activity and the microscopic and clin[...]texto impreso
Coffey, Lark L. ; Durand, Benoit ; Lecollinet, Sylvie ; Beck, Cécile ; Martínez López, Beatriz ; Balenghien, Thomas ; Chevalier, Véronique | Public Library Science | 2013Live animal trade is considered a major mode of introduction of viruses from enzootic foci into disease-free areas. Due to societal and behavioural changes, some wild animal species may nowadays be considered as pet species. The species diversit[...]texto impreso
Nieves Moreno, María ; Martínez de la Casa, Jose Maria ; Morales Fernández, Laura ; Sánchez Jean, Rubén ; Sáenz Francés, Federico ; García Feijoo, Julián | Public Library Science | 2018-03-09Objective: To examine differences in individual retinal layer thicknesses measured by spectral domain optical coherence tomography (SD-OCT) (Spectralis®) produced with age and according to sex. Design: Cross-sectional, observational study. Metho[...]texto impreso
Gubbins, Simon ; Costard, Solenne ; Jones, Bryony Anne ; Martínez López, Beatriz ; Mur, Lina ; De la Torre, Ana ; Martínez, Marta ; Sánchez Vizcaíno, Fernando ; Sánchez-Vizcaíno, José Manuel ; Pfeiffer, Dirk Udo ; Wieland, Barbara | Public Library Science | 2013Transboundary animal diseases can have very severe socio-economic impacts when introduced into new regions. The history of disease incursions into the European Union suggests that initial outbreaks were often initiated by illegal importation of [...]texto impreso
Rigottier-Gois, Lionel ; Alberti, Adriana ; Houel, Armel ; Taly, Jean-François ; Palcy, Philippe ; Manson, Janet ; Pinto, Daniela ; Matos, Renata C ; Carrilero Aguado, Laura ; Montero Serra, Natalia ; Tariq, Muhammad ; Karsens, Harma ; Repp, Christian ; Kropec, Andrea ; Budin-Verneuil, Aurélie ; Benachour, Abdellah ; Sauvageot, Nicolas ; Bizzini, Alain ; Gilmore, Michael S ; Bessières, Philippe ; Kok, Jan ; Huebner, Johannes ; Lopes, Fatima ; González Zorn, Bruno ; Hartke, Axel ; Serror, Pascale | Public Library Science | 2011Spread of antibiotic resistance among bacteria responsible for nosocomial and community-acquired infections urges for novel therapeutic or prophylactic targets and for innovative pathogen-specific antibacterial compounds. Major challenges are po[...]texto impreso
Alba, Patricia ; Feltrin, Fabiola ; Cordaro, Gessica ; Porrero, María Concepción ; Kraushaar, Britta ; Argudín, María Angeles ; Nykäsenoja, Suvi ; Monaco, Monica ; Stegger, Marc ; Aarestrup, Frank M ; Butaye, Patrick ; Franco, Alessia ; Battisti, Antonio | Public Library Science | 2015Methicillin-resistant Staphylococcus aureus (MRSA) Sequence Type (ST)1, Clonal Complex(CC)1, SCCmec V is one of the major Livestock-Associated (LA-) lineages in pig farming industry in Italy and is associated with pigs in other European countrie[...]texto impreso
Mentaberre, Gregorio ; Romero Martínez, Beatriz ; Juan Ferré, Lucia de ; Navarro González, Nora ; Velarde, Roser ; Mateos García, Ana ; Marco, Ignasi ; Olivé-Boix, Xavier ; Domínguez Rodríguez, Lucas ; Lavín, Santiago ; Serrano, Emmanuel | Public Library Science | 2014Wild boar is a recognized reservoir of bovine tuberculosis (TB) in the Mediterranean ecosystems, but information is scarce outside of hotspots in southern Spain. We describe the first high-prevalence focus of TB in a non-managed wild boar popula[...]texto impreso
Background: Mycobacterium tuberculosis is a particularly aggressive microorganism and the host's defense is based on the induction of cellular immunity, in which the creation of a granulomatous structure has an important role. Methodology: We pr[...]texto impreso
Granberg, Fredrik ; Vicente Rubiano, Marina ; Rubio Guerri, Consuelo ; Karlsson, Oskar E ; Kukielka, Deborah ; Belák, Sándor ; Sánchez-Vizcaíno, José Manuel | Public Library Science | 2013The situation in Europe concerning honeybees has in recent years become increasingly aggravated with steady decline in populations and/or catastrophic winter losses. This has largely been attributed to the occurrence of a variety of known and "u[...]texto impreso
Cardoso Toset, Fernando ; Gómez Laguna, Jaime ; Amarilla, Shyrley P ; Vela Alonso, Ana ; Carrasco, Librado ; Fernández Garayzábal, José F ; Astorga, Rafael J ; Luque, Inmaculada | Public Library Science | 2015Tuberculosis-like lesions (TBL) in pigs have been associated with microorganisms other than mycobacteria. In this work a histopathological and microbiological evaluation of TBL in pigs is shown. A total of 352 samples belonging to 171 pigs total[...]texto impreso
Fernández Navarro, Judith ; Aldea Mansilla, Pilar ; Hoz Montañana, María Rosa de ; Salazar Corral, Juan José ; Ramírez Sebastián, Ana Isabel ; Rojas López, Blanca ; Gallego Collado, Beatriz Isabel ; Triviño Casado, Alberto ; Tejerina Sánchez, Teresa ; Ramirez Sebastian, Jose Manuel | Public Library Science | 2016-05-04To evaluate the pleiotropic effects to statins, we analyze the qualitative and quantitative retinal changes in hypercholesterolemic rabbits after a low-dosage statin treatment. For this purpose, New Zealand rabbits were split into three groups: [...]texto impreso
Pavón Carrasco, Francisco Javier ; Osete López, María Luisa ; Arquero Campuzano, Saioa ; De Santis, Angelo ; Qamili, Enkelejda | Public Library Science | 2018-11-15The debated question on the possible relation between the Earth's magnetic field and climate has been usually focused on direct correlations between different time series representing both systems. However, the physical mechanism able to potenti[...]texto impreso
Nieves Moreno, María ; Martínez de la Casa, Jose Maria ; Cifuentes Canorea, Pilar ; Sastre Ibáñez, Marina ; Santos Bueso, Enrique ; Sáenz Francés, Federico ; Morales Fernández, Laura ; García Feijoo, Julián | Public Library Science | 2017-07-05Purpose: Develop the first normative database of the thickness of every inner retinal layer in the macular area in a healthy, Caucasian population between 18 to 87 years old, using Spectralis Optical Coherence Tomography (OCT). Methods: On this [...]texto impreso
Beltrán-Beck, Beatriz ; De la Fuente, Jose ; Garrido, Joseba M ; Aranaz Martín, Alicia ; Sevilla, Iker ; Villar, Margarita ; Boadella, Mariana ; Galindo, Ruth C ; Pérez de la Lastra, José M ; Moreno Cid, Juan A ; Fernández de Mera, Isabel G ; Alberdi, Pilar ; Santos, Gracia ; Ballesteros, Cristina ; Lyashchenko, Konstantin P ; Minguijón, Esmeralda ; Romero Martínez, Beatriz ; Juan Ferré, Lucia de ; Domínguez Rodríguez, Lucas ; Juste, Ramón ; Gortazar, Christian | Public Library Science | 2014Tuberculosis (TB) remains a pandemic affecting billions of people worldwide, thus stressing the need for new vaccines. Defining the correlates of vaccine protection is essential to achieve this goal. In this study, we used the wild boar model fo[...]texto impreso
Ortiz, Tomás ; Poch, Joaquín ; Santos, Juan M. ; Requena, Carmen ; Martínez, Ana M. ; Ortiz Terán, Laura ; Turrero, Agustín ; Barcia, Juan ; Nogales, Ramón ; Calvo, Agustín ; Martínez, José M. ; Córdoba, José L. ; Pascual Leone, Álvaro | Public Library Science | 2011Over three months of intensive training with a tactile stimulation device, 18 blind and 10 blindfolded seeing subjects improved in their ability to identify geometric figures by touch. Seven blind subjects spontaneously reported 'visual qualia',[...]texto impreso
Vicente-Tejedor, Javier ; Marchena, Miguel ; Ramirez, Laura ; García Ayuso, Diego ; Gómez Vicente, Violeta ; Sánchez Ramos, Celia ; Villa Polo, Pedro de la ; Germain, Francisco | Public Library Science | 2018-03-15Light causes damage to the retina (phototoxicity) and decreases photoreceptor responses to light. The most harmful component of visible light is the blue wavelength (400–500 nm). Different filters have been tested, but so far all of them allow p[...]texto impreso
Hoz Montañana, María Rosa de ; Gallego Collado, Beatriz Isabel ; Ramírez Sebastián, Ana Isabel ; Rojas López, María Blanca ; Salazar Corral, Juan José ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Public Library Science | 2013-12-18In the mouse model of unilateral laser-induced ocular hypertension (OHT) the microglia in both the treated and the normotensive untreated contralateral eye have morphological signs of activation and up-regulation of MHC-II expression in comparis[...]texto impreso
Domingo Martínez, Laura ; Barroso-Barcenilla, Fernando ; Cambra-Moo, Oscar | Public Library Science | 2015-03Isotopic studies of multi-taxa terrestrial vertebrate assemblages allow determination of paleoclimatic and paleoecological aspects on account of the different information supplied by each taxon. The late Campanian-early Maastrichtian “Lo Hueco” [...]texto impreso
Cruz Conty, Maria Luisa de la ; Perez, Andrés ; Bezos Garrido, Javier ; Pages, Enrique ; Casal, Carmen ; Carpintero, Jesus ; Romero Martínez, Beatriz ; Domínguez Rodríguez, Lucas ; Barker, Christopher M ; Diaz, Rosa ; Álvarez Sánchez, Julio | Public Library Science | 2014Progress in control of bovine tuberculosis (bTB) is often not uniform, usually due to the effect of one or more sometimes unknown epidemiological factors impairing the success of eradication programs. Use of spatial analysis can help to identify[...]texto impreso
Salazar Corral, Juan José ; Gallego-Pinazo, Roberto ; Hoz Montañana, María Rosa de ; Pinazo-Durán, María Dolores ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Serrano Espinosa, Manuel ; Ramirez Sebastian, Jose Manuel | Public Library Science | 2013-06-07Tumour-suppressor genes, such as the p53 gene, produce proteins that inhibit cell division under adverse conditions, as in the case of DNA damage, radiation, hypoxia, or oxidative stress (OS). The p53 gene can arrest proliferation and trigger de[...]texto impreso
Acevedo, Pelayo ; Romero Martínez, Beatriz ; Vicente, Joaquín ; Caracappa, Santo ; Galluzzo, Paola ; Marineo, Sandra ; Vicari, Domenico ; Torina, Alessandra ; Casal, Carmen ; De la Fuente, Jose ; Gortazar, Christian | Public Library Science | 2013Because of their relative simplicity and the barriers to gene flow, islands are ideal systems to study the distribution of biodiversity. However, the knowledge that can be extracted from this peculiar ecosystem regarding epidemiology of economic[...]texto impreso
Camicia, Federico ; Celentano, Ana M. ; Johns, Malcolm E. ; Chan, John D. ; Maldonado, Lucas ; Vaca, Hugo ; Siervi, Nicolás Di ; Kamenetzky, Laura ; Gamo Albero, Ana María ; Ortega Gutiérrez, Silvia ; Martín Fontecha, María del Mar ; Davio, Carlos ; Marchant, Jonathan S. ; Rosenzvit, Mara C. | Public Library Science | 2018-02-09Background: Cestodes are a diverse group of parasites, some of them being agents of neglected diseases. In cestodes, little is known about the functional properties of G protein coupled receptors (GPCRs) which have proved to be highly druggable [...]texto impreso
Investigation of mechanisms of information handling in neural assemblies involved in computational and cognitive tasks is a challenging problem. Synergetic cooperation of neurons in time domain, through synchronization of firing of multiple spat[...]texto impreso
Reboredo, Mercedes ; Chang, Haisul C. Y. ; Barbero, Roberto ; Rodríguez Ortigosa, Carlos M. ; Pérez Vizcaino, Francisco ; Morán, Asunción ; García, Mónica ; Banales, Jesus ; Carreño, Norberto ; Alegre, Félix ; Herrero, Ignacio ; Quiroga, Jorge ; Prieto, Jesús ; Sangro, Bruno | Public Library Science | 2013-01-16Objective: Only a limited proportion of patients needing pharmacological control of portal hypertension are hemodynamic responders to propranolol. Here we analyzed the effects of zolmitriptan on portal pressure and its potential interaction with[...]