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Título:
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Effects of dosage, comorbidities, and food on isoniazid pharmacokinetics in Peruvian tuberculosis patients
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Autores:
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Requena-Mendez, Ana ;
Davies, Geraint ;
Waterhouse, David ;
Ardrey, Alison ;
Jave, Oswaldo ;
Lopez-Romero, Sonia Llanet ;
Ward, Stephen A. ;
Moore, David A. J.
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Tipo de documento:
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texto impreso
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Editorial:
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American Society for Microbiology, 2020-06-10T18:11:36Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Poor response to tuberculosis (TB) therapy might be attributable to subtherapeutic levels in drug-compliant patients. Pharmacokinetic (PK) parameters can be affected by several factors, such as comorbidities or the interaction of TB drugs with food. This study aimed to determine the PK of isoniazid (INH) in a Peruvian TB population under observed daily and twice-weekly (i.e., biweekly) therapy. Isoniazid levels were analyzed at 2 and 6 h after drug intake using liquid chromatography mass spectrometric methods. A total of 107 recruited patients had available PK data; of these 107 patients, 42.1% received biweekly isoniazid. The mean biweekly dose (12.8 mg/kg of body weight/day) was significantly lower than the nominal dose of 15 mg/kg/day (P
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En línea:
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http://doi.org/10.1128/AAC.03258-14
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