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Título:
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Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis
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Autores:
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Ong, Catherine W. M. ;
Elkington, Paul T. ;
Brilha, Sara ;
Ugarte-Gil, Cesar ;
Tome-Esteban, Maite T. ;
Tezera, Liku B. ;
Pabisiak, Przemyslaw J. ;
Moores, Rachel C. ;
Sathyamoorthy, Tarangini ;
Patel, Vimal ;
Gilman, Robert H. ;
Porter, Joanna C. ;
Friedland, Jon S.
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Tipo de documento:
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texto impreso
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Editorial:
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Public Library of Science, 2019-02-06T14:53:12Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix destruction resulting in cavitation is not well defined. Neutrophils are emerging as key mediators of TB immunopathology and their influx are associated with poor outcomes. We investigated neutrophil-dependent mechanisms involved in
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En línea:
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http://doi.org/10.1371/journal.ppat.1004917
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