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Título:
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Antihypertensive Agents in Older Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
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Autores:
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Murad, Mohammad Hassan ;
Larrea-Mantilla, Laura ;
Haddad, Abdullah ;
Spencer-Bonilla, Gabriela ;
Serrano, Valentina ;
Rodriguez-Gutierrez, Rene ;
Alvarez-Villalobos, Neri ;
Benkhadra, Khaled ;
Gionfriddo, Michael R. ;
Prokop, Larry J. ;
Brito, Juan P. ;
Ponce, Oscar J.
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Tipo de documento:
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texto impreso
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Editorial:
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Oxford University Press, 2019-07-04T16:59:19Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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BACKGROUND: This systematic review summarizes the benefits of treating blood pressure (BP) in individuals 65 years and older. METHODS: We included randomized trials that evaluated BP-lowering medications or BP targets in individuals 65 years and older. Trials were selected and appraised by pairs of independent reviewers. RESULTS: We included 19 trials (42,134 patients). In individuals 65 years or older, antihypertensive therapy was associated with a reduction in all-cause mortality [relative risk: 0.88 (95% CI: 0.81 to 0.94); high certainty evidence; mean follow-up 31 months], cardiovascular mortality, myocardial infarction, heart failure, stroke, and chronic kidney disease. Individuals 75 years or older had a significant reduction in the risk of all-cause and cardiovascular mortality, stroke, and heart failure. Strict systolic BP targets (
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En línea:
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http://doi.org/10.1210/jc.2019-00197
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