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Título:
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Global REACH 2018: High Blood Viscosity and Hemoglobin Concentration Contribute to Reduced Flow-Mediated Dilation in High-Altitude Excessive Erythrocytosis
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Autores:
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Tremblay, Joshua C. ;
Hoiland, Ryan L. ;
Howe, Connor A. ;
Coombs, Geoff B. ;
Vizcardo-Galindo, Gustavo A. ;
Figueroa-Mujica, Romulo J. ;
Bermudez, Daniela ;
Gibbons, Travis D. ;
Stacey, Benjamin S. ;
Bailey, Damian M. ;
Tymko, Michael M. ;
MacLeod, David B. ;
Gasho, Chris ;
Villafuerte, Francisco C. ;
Pyke, Kyra E. ;
Ainslie, Philip N.
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Tipo de documento:
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texto impreso
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Editorial:
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American Heart Association, 2019-12-06T20:57:40Z
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Nota general:
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info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Excessive erythrocytosis (EE; hemoglobin concentration [Hb] >/=21 g/dL in adult males) is associated with increased cardiovascular risk in highlander Andeans. We sought to quantify shear stress and assess endothelial function via flow-mediated dilation (FMD) in male Andeans with and without EE. We hypothesized that FMD would be impaired in Andeans with EE after accounting for shear stress and that FMD would improve after isovolemic hemodilution. Brachial artery shear stress and FMD were assessed in 23 male Andeans without EE (age: 40+/-15 years [mean+/-SD]; Hb/=21 g/dL) in Cerro de Pasco, Peru (4330 m). Shear stress was quantified from Duplex ultrasound measures of shear rate and blood viscosity. In a subset of participants (n=8), FMD was performed before and after isovolemic hemodilution with blood volume replaced by an equal volume of human serum albumin. Blood viscosity and Hb were 48% and 23% higher (both P
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En línea:
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http://repositorio.upch.edu.pe/handle/upch/7358
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