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Título:
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Admixture in Latin America: geographic structure, phenotypic diversity and self-perception of ancestry based on 7,342 individuals
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Autores:
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Ruiz-Linares, Andrés ;
Adhikari, Kaustubh ;
Acuna-Alonzo, Victor ;
Quinto-Sanchez, Mirsha ;
Jaramillo, Claudia ;
Arias, William ;
Fuentes, Macarena ;
Pizarro, Maria ;
Everardo, Paola ;
de Avila, Francisco ;
Gomez-Valdes, Jorge ;
Leon-Mimila, Paola ;
Hunemeier, Tabita ;
Ramallo, Virginia ;
Silva de Cerqueira, Caio C. ;
Burley, Mari-Wyn ;
Konca, Esra ;
de Oliveira, Marcelo Zagonel ;
Veronez, Mauricio Roberto ;
Rubio-Codina, Marta ;
Attanasio, Orazio ;
Gibbon, Sahra ;
Ray, Nicolas ;
Gallo, Carla ;
Poletti, Giovanni ;
Rosique, Javier ;
Schuler-Faccini, Lavinia ;
Salzano, Francisco M. ;
Bortolini, Maria-Cátira ;
Canizales-Quinteros, Samuel ;
Rothhammer, Francisco ;
Bedoya, Gabriel ;
Balding, David ;
González-José, Rolando
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Tipo de documento:
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texto impreso
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Editorial:
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Public Library of Science, 2020-06-10T18:12:16Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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The current genetic makeup of Latin America has been shaped by a history of extensive admixture between Africans, Europeans and Native Americans, a process taking place within the context of extensive geographic and social stratification. We estimated individual ancestry proportions in a sample of 7,342 subjects ascertained in five countries (Brazil, Chile, Colombia, Mexico and Peru). These individuals were also characterized for a range of physical appearance traits and for self-perception of ancestry. The geographic distribution of admixture proportions in this sample reveals extensive population structure, illustrating the continuing impact of demographic history on the genetic diversity of Latin America. Significant ancestry effects were detected for most phenotypes studied. However, ancestry generally explains only a modest proportion of total phenotypic variation. Genetically estimated and self-perceived ancestry correlate significantly, but certain physical attributes have a strong impact on self-perception and bias self-perception of ancestry relative to genetically estimated ancestry.
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En línea:
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http://doi.org/10.1371/journal.pgen.1004572
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