Título:
|
Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines
|
Autores:
|
Hernández, Wilfredo ;
Paz, Juan ;
Carrasco, Fernando ;
Vaisberg, Abraham ;
Spodine, Evgenia ;
Manzur, Jorge ;
Hennig, Lothar ;
Sieler, Joachim ;
Blaurock, Steffen ;
Beyer, Lothar
|
Tipo de documento:
|
texto impreso
|
Editorial:
|
Hindawi Publishing Corporation, 2019-02-06T14:52:14Z
|
Nota general:
|
info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
|
Idiomas:
|
Inglés
|
Palabras clave:
|
Editados por otras instituciones
,
Artículos
,
Artículos en revistas indizadas
|
Resumen:
|
The palladium(II) bis-chelate complexes of the type [Pd(TSC1-5)2] (6–10), with their corresponding ligands 4-phenyl-1-(acetone)-thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2?-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3?-hydroxy-benzaldehyde)-thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2?-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl-1-(1?-nitro-2?-naphthaldehyde)-thiosemicarbazone, HTSC5 (5), were synthesized and characterized by elemental analysis and spectroscopic techniques (IR and 1H- and 13C-NMR). The molecular structure of HTSC3, HTSC4, and [Pd(TSC1)2] (6) have been determined by single crystal X-ray crystallography. Complex 6 shows a square planar geometry with two deprotonated ligands coordinated to PdII through the azomethine nitrogen and thione sulfur atoms in a cis arrangement. The in vitro cytotoxic activity measurements indicate that the palladium(II) complexes ((IC50 = 0.01–9.87 ?M) exhibited higher antiproliferative activity than their free ligands ((IC50 = 23.48–70.86 and >250 ?M) against different types of human tumor cell lines. Among all the studied palladium(II) complexes, the [Pd(TSC3)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma and K562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02??M, resp.).
|
En línea:
|
http://doi.org/10.1155/2013/524701
|