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Título:
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A Peruvian family with a high burden of HTLV-1-associated myelopathy/tropical spastic paraparesis
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Autores:
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Alvarez, Carolina ;
Verdonck, Kristien ;
Tipismana, Martin ;
Gotuzzo, Eduardo
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Tipo de documento:
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texto impreso
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Editorial:
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BMJ Publishing Group, 2019-02-06T14:59:05Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Human T-lymphotropic virus 1 (HTLV-1) is frequent in Peru; an estimated 1–2% of the Peruvian population carry this retrovirus. HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic disabling disease that affects about 1% of the carriers of HTLV-1. It is not yet known why some HTLV-1-infected people develop HAM/TSP while others do not. In this case report, we present a family with an unusually high burden of HAM/TSP: 5 (the 2 parents and 3 of their children) of 7 HTLV-1 carriers developed the same disease. We describe the clinical presentation and discuss the clustering of disease against the current knowledge of the pathogenesis of HAM/TSP. Families such as this may hold the key to discovering which factors trigger the development of HAM/TSP.
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En línea:
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http://doi.org/10.1136/bcr-2015-209619
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