|
Título:
|
Long-Term Intermittent Exposure to High Altitude Elevates Asymmetric Dimethylarginine in First Exposed Young Adults
|
|
Autores:
|
Lüneburg, Nicole ;
Siques, Patricia ;
Brito, Julio ;
De La Cruz, Juan Jose ;
Leon-Velarde, Fabiola ;
Hannemann, Juliane ;
Ibanez, Cristian ;
Boger, Rainer H.
|
|
Tipo de documento:
|
texto impreso
|
|
Editorial:
|
Mary Ann Liebert, 2019-01-25T15:28:05Z
|
|
Nota general:
|
info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
|
|
Idiomas:
|
Inglés
|
|
Palabras clave:
|
Editados por otras instituciones
,
Artículos
,
Artículos en revistas indizadas
|
|
Resumen:
|
Hypoxia-induced dysregulation of pulmonary and cerebral circulation may be related to an impaired nitric oxide (NO) pathway. We investigated the effect of chronic intermittent hypobaric hypoxia (CIH) on metabolites of the NO pathway. We measured asymmetric and symmetric dimethylarginine (ADMA and SDMA) and monomethyl-L-arginine (L-NMMA) and assessed their associations with acclimatization in male draftees (n = 72) undergoing CIH shifts at altitude (3550 m) during 3 months. Sixteen Andean natives living at altitude (3675 m) (chronic hypobaric hypoxia [CH]) were included for comparison. In CIH, ADMA and L-NMMA plasma concentrations increased from 1.14 +/- 0.04 to 1.95 +/- 0.09 mumol/L (mean +/- SE) and from 0.22 +/- 0.07 to 0.39 +/- 0.03 mumol/L, respectively, (p
|
|
En línea:
|
http://doi.org/10.1089/ham.2016.0123
|
