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Título:
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Myeloproliferative neoplasms with t(8;22)(p11.2;q11.2)/BCR-FGFR1: a meta-analysis of 20 cases shows cytogenetic progression with B-lymphoid blast phase
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Autores:
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Montenegro-Garreaud, Ximena ;
Miranda, Roberto N. ;
Reynolds, Alexandra ;
Tang, Guilin ;
Wang, Sa A. ;
Yabe, Mariko ;
Wang, Wei ;
Fang, Lianghua ;
Bueso-Ramos, Carlos E. ;
Lin, Pei ;
Medeiros, L. Jeffrey ;
Lu, Xinyan
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Tipo de documento:
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texto impreso
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Editorial:
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Elsevier, 2019-01-25T15:28:06Z
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Nota general:
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info:eu-repo/semantics/restrictedAccess
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
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Idiomas:
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Inglés
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Palabras clave:
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Editados por otras instituciones
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Artículos
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Artículos en revistas indizadas
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Resumen:
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Rearrangements of FGFR1 result in the 8p11 myeloproliferative syndrome, a group of rare diseases that features a myeloproliferative neoplasm (MPN) that commonly progresses to lymphoblastic leukemia/lymphoma or acute myeloid leukemia. The most common partner of FGFR1 is ZMYM2, and patients with the ZMYM2-FGFR1 fusion often present with MPN and T-lymphoblastic lymphoma. There are 14 other partners that can fuse with FGFR1, and of interest is the BCR-FGFR1 fusion that results from t(8;22)(p11.2;q11.2). Patients with t(8;22) often show leukocytosis and present with an MPN resembling chronic myeloid leukemia or very rarely, with
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En línea:
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http://doi.org/10.1016/j.humpath.2017.05.008
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